Research Data

acetylcholin, response inhibition and attention (ARA-study)

Author(s) / Creator(s)

Schote-Frese, Andrea

Abstract / Description

People showing symptoms of attention deficit hyperactivity disorder (ADHD) often present an impairment of reaction time and response inhibition. These executive functions are influenced by nicotinergic acetylcholine receptors (nAchr) as mediators of cholinergic signalling, and show differences between both sexes. We examined the effects of two functional polymorphismsrs3841324 (S/L) and rs16969968 (G/A) of the α5 subunit encoding gene CHRNA5, ADHD symptoms and sex on response inhibition/reaction time in the Stop Signal Task. In the analyses, 183 participants (52.4 % females) were included. In participants carrying the diplotype (SS_GG), men with ADHD symptoms responded faster, while men without ADHD symptoms were slower than women (F = 5.313; p = 0.023; η² = 0.034). Although explorative, this threefold interaction on reaction time but not response inhibition extend previous findings, suggesting a moderating effect of the CHRNA5 diplotype SS_GG in male carriers with ADHD symptoms and might inspire research on genotype- and gender-specific ADHD medication.
Dataset for: Andrea B. Schote, Clara A. L. Sayk, Kathrin Pabst, Jacqueline K. Meier, Christian Frings, Jobst Meyer (2018). Sex, ADHD symptoms & CHRNA5 genotype influence reaction time but not response inhibition. In: Journal of Neuroscience Research. https://doi.org/10.1002/jnr.24342

Keyword(s)

genetics responce inhibition ADHD

Persistent Identifier

Date of first publication

2018

Publisher

ZPID (Leibniz Institute for Psychology Information)

Citation

Schote-Frese, A. (2018). acetylcholin, response inhibition and attention (ARA-study) [Data set]. ZPID (Leibniz Institute for Psychology Information). https://doi.org/10.23668/psycharchives.911
  • Author(s) / Creator(s)
    Schote-Frese, Andrea
  • PsychArchives acquisition timestamp
    2018-09-12T11:09:34Z
  • Made available on
    2018-09-12T11:09:34Z
  • Date of first publication
    2018
  • Abstract / Description
    People showing symptoms of attention deficit hyperactivity disorder (ADHD) often present an impairment of reaction time and response inhibition. These executive functions are influenced by nicotinergic acetylcholine receptors (nAchr) as mediators of cholinergic signalling, and show differences between both sexes. We examined the effects of two functional polymorphismsrs3841324 (S/L) and rs16969968 (G/A) of the α5 subunit encoding gene CHRNA5, ADHD symptoms and sex on response inhibition/reaction time in the Stop Signal Task. In the analyses, 183 participants (52.4 % females) were included. In participants carrying the diplotype (SS_GG), men with ADHD symptoms responded faster, while men without ADHD symptoms were slower than women (F = 5.313; p = 0.023; η² = 0.034). Although explorative, this threefold interaction on reaction time but not response inhibition extend previous findings, suggesting a moderating effect of the CHRNA5 diplotype SS_GG in male carriers with ADHD symptoms and might inspire research on genotype- and gender-specific ADHD medication.
    en_US
  • Abstract / Description
    Dataset for: Andrea B. Schote, Clara A. L. Sayk, Kathrin Pabst, Jacqueline K. Meier, Christian Frings, Jobst Meyer (2018). Sex, ADHD symptoms & CHRNA5 genotype influence reaction time but not response inhibition. In: Journal of Neuroscience Research. https://doi.org/10.1002/jnr.24342
  • Review status
    unknown
  • Citation
    Schote-Frese, A. (2018). acetylcholin, response inhibition and attention (ARA-study) [Data set]. ZPID (Leibniz Institute for Psychology Information). https://doi.org/10.23668/psycharchives.911
    en
  • Persistent Identifier
    https://hdl.handle.net/20.500.12034/710
  • Persistent Identifier
    https://doi.org/10.23668/psycharchives.911
  • Language of content
    eng
    en_US
  • Publisher
    ZPID (Leibniz Institute for Psychology Information)
    en_US
  • Is related to
    https://doi.org/10.1002/jnr.24342
  • Keyword(s)
    genetics
    en_US
  • Keyword(s)
    responce inhibition
    en_US
  • Keyword(s)
    ADHD
    en_US
  • Dewey Decimal Classification number(s)
    150
  • Title
    acetylcholin, response inhibition and attention (ARA-study)
    en_US
  • DRO type
    researchData
    en_US