Research Data

Dataset for: Repeated low doses of LSD in healthy adults: A placebo-controlled, dose-response study

Author(s) / Creator(s)

Molla, Hanna

Abstract / Description

Dataset for: de Wit, H., Molla, H. M., Bershad, A., Bremmer, M., & Lee, R. (2022). Repeated low doses of LSD in healthy adults: A placebo‐controlled, dose–response study. Addiction Biology, 27(2). https://doi.org/10.1111/adb.13143
The resurgence of interest in using psychedelic drugs, including lysergic acid diethylamide (LSD), in psychiatry has drawn attention to the medically unsupervised practice of ‘microdosing’. Thousands of users claim that very low doses of LSD, taken at 3–4-day intervals, improve mood and cognitive function., However, few controlled studies have described the effects of the drug when taken in this way. Here, in a double-blind controlled study, we studied the effects of four repeated doses of LSD tartrate (13 or 26 μg) or placebo, administered to healthy adults at 3–4 day intervals, on mood, cognitive performance and responses to emotional tasks. Participants were randomly assigned to one of three drug conditions: placebo (N = 18), 13 μg LSD (N = 19), or 26 μg LSD (N = 19). They attended four 5-hour drug-administration sessions separated by 3–4 days, followed by a drug-free follow-up session 3–4 days after the last session. LSD (26 μg) produced modest subjective effects including increased ratings of ‘feeling a drug effect’ and both stimulant-like and LSD-like effects, but the drug did not improve mood or affect performance on psychomotor or most emotional tasks. No residual effects were detected on mood or task performance on the drug-free follow-up session. We conclude that within the context of a controlled setting and a limited number of administrations, repeated low doses of LSD are safe, but produce negligible changes in mood or cognition in healthy volunteers.

Keyword(s)

behavior cognition LSD microdosing mood psychopharmacology

Persistent Identifier

Date of first publication

2021-10-12

Publisher

PsychArchives

Is referenced by

Citation

Molla, H. (2021). Dataset for: Repeated low doses of LSD in healthy adults: A placebo-controlled, dose-response study [Data set]. PsychArchives. https://doi.org/10.23668/PSYCHARCHIVES.5153
  • Author(s) / Creator(s)
    Molla, Hanna
  • PsychArchives acquisition timestamp
    2021-10-12T06:15:30Z
  • Made available on
    2021-10-12T06:15:30Z
  • Date of first publication
    2021-10-12
  • Abstract / Description
    Dataset for: de Wit, H., Molla, H. M., Bershad, A., Bremmer, M., & Lee, R. (2022). Repeated low doses of LSD in healthy adults: A placebo‐controlled, dose–response study. Addiction Biology, 27(2). https://doi.org/10.1111/adb.13143
    en
  • Abstract / Description
    The resurgence of interest in using psychedelic drugs, including lysergic acid diethylamide (LSD), in psychiatry has drawn attention to the medically unsupervised practice of ‘microdosing’. Thousands of users claim that very low doses of LSD, taken at 3–4-day intervals, improve mood and cognitive function., However, few controlled studies have described the effects of the drug when taken in this way. Here, in a double-blind controlled study, we studied the effects of four repeated doses of LSD tartrate (13 or 26 μg) or placebo, administered to healthy adults at 3–4 day intervals, on mood, cognitive performance and responses to emotional tasks. Participants were randomly assigned to one of three drug conditions: placebo (N = 18), 13 μg LSD (N = 19), or 26 μg LSD (N = 19). They attended four 5-hour drug-administration sessions separated by 3–4 days, followed by a drug-free follow-up session 3–4 days after the last session. LSD (26 μg) produced modest subjective effects including increased ratings of ‘feeling a drug effect’ and both stimulant-like and LSD-like effects, but the drug did not improve mood or affect performance on psychomotor or most emotional tasks. No residual effects were detected on mood or task performance on the drug-free follow-up session. We conclude that within the context of a controlled setting and a limited number of administrations, repeated low doses of LSD are safe, but produce negligible changes in mood or cognition in healthy volunteers.
    en
  • Review status
    unknown
  • Sponsorship
    National Institute on Drug Abuse. Grant Number: DA02812 / University of Chicago Medical Scientist Training program / National Institute of Health/National Institute of General Medical Sciences. Grant Number: T32GM007019 / Institute of Translational Medicine at the University of Chicago. Grant Number: UL1 RR024999
    en
  • Citation
    Molla, H. (2021). Dataset for: Repeated low doses of LSD in healthy adults: A placebo-controlled, dose-response study [Data set]. PsychArchives. https://doi.org/10.23668/PSYCHARCHIVES.5153
    en
  • Persistent Identifier
    https://hdl.handle.net/20.500.12034/4571
  • Persistent Identifier
    https://doi.org/10.23668/psycharchives.5153
  • Language of content
    eng
  • Publisher
    PsychArchives
  • Is referenced by
    https://doi.org/10.1111/adb.13143
  • Is related to
    https://doi.org/10.1111/adb.13143
  • Keyword(s)
    behavior
    en
  • Keyword(s)
    cognition
    en
  • Keyword(s)
    LSD
    en
  • Keyword(s)
    microdosing
    en
  • Keyword(s)
    mood
    en
  • Keyword(s)
    psychopharmacology
    en
  • Dewey Decimal Classification number(s)
    150
  • Title
    Dataset for: Repeated low doses of LSD in healthy adults: A placebo-controlled, dose-response study
    en
  • DRO type
    researchData