mGlu5: A double-edged sword for aversive learning related therapeutics
Author(s) / Creator(s)
Tan, Shawn Zheng Kai
Kim, Jee Hyun
Abstract / Description
Aversive memories underlie many types of anxiety disorders. One area of research to more effectively treat anxiety disorders has therefore been identifying pharmacological targets to affect memory processes. Among these targets, the metabotropic glutamate 5 receptor (mGlu5) has received attention due to the availability of drugs to utilize its role in learning and memory. In this review, we highlight preclinical studies examining the role of mGlu5 at various stages of aversive learning and its inhibition via extinction in order to gain a better understanding of its therapeutic potential. We suggest that mGlu5 has distinct roles at different stages of memory that not only makes it a tricky target, but a double-edged sword as a therapeutic. However, the selective involvement of mGlu5 in different memory stages allows for certain precision that could be harnessed clinically. We therefore suggest potential applications, limitations, and pitfalls when considering use of mGlu5 modulators as therapeutics. In addition, we recommend future studies to address important gaps in this literature, such as sex and age factors in light of anxiety disorders being more prevalent in those demographics.
Keyword(s)
mGlu5 Learning and Memory Aversive Learning Fear ConditioningPersistent Identifier
Date of first publication
2021-01-18
Journal title
Neuroanatomy and Behaviour
Volume
3
Article number
e16
Publisher
Episteme Health Inc.
Publication status
publishedVersion
Review status
peerReviewed
Is version of
Citation
Tan, S. Z. K., & Kim, J. H. (2021). mGlu5: A double-edged sword for aversive learning related therapeutics. Neuroanatomy and Behaviour, 3, e16. http://dx.doi.org/10.23668/psycharchives.4843
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nab.2021.e16.pdfAdobe PDF - 280.61KBMD5: 7401245e1741e36bb2b0b22e006bd72cDescription: Version of Record
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There are no other versions of this object.
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Author(s) / Creator(s)Tan, Shawn Zheng Kai
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Author(s) / Creator(s)Kim, Jee Hyun
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PsychArchives acquisition timestamp2021-05-17T14:39:08Z
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Made available on2021-05-17T14:39:08Z
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Date of first publication2021-01-18
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Abstract / DescriptionAversive memories underlie many types of anxiety disorders. One area of research to more effectively treat anxiety disorders has therefore been identifying pharmacological targets to affect memory processes. Among these targets, the metabotropic glutamate 5 receptor (mGlu5) has received attention due to the availability of drugs to utilize its role in learning and memory. In this review, we highlight preclinical studies examining the role of mGlu5 at various stages of aversive learning and its inhibition via extinction in order to gain a better understanding of its therapeutic potential. We suggest that mGlu5 has distinct roles at different stages of memory that not only makes it a tricky target, but a double-edged sword as a therapeutic. However, the selective involvement of mGlu5 in different memory stages allows for certain precision that could be harnessed clinically. We therefore suggest potential applications, limitations, and pitfalls when considering use of mGlu5 modulators as therapeutics. In addition, we recommend future studies to address important gaps in this literature, such as sex and age factors in light of anxiety disorders being more prevalent in those demographics.en
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Publication statuspublishedVersionen
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Review statuspeerRevieweden
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CitationTan, S. Z. K., & Kim, J. H. (2021). mGlu5: A double-edged sword for aversive learning related therapeutics. Neuroanatomy and Behaviour, 3, e16. http://dx.doi.org/10.23668/psycharchives.4843en
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ISSN2652-1768
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Persistent Identifierhttps://hdl.handle.net/20.500.12034/4280
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Persistent Identifierhttps://doi.org/10.23668/psycharchives.4843
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Language of contenteng
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PublisherEpisteme Health Inc.en
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Is version ofhttps://doi.org/10.35430/nab.2021.e16
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Keyword(s)mGlu5
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Keyword(s)Learning and Memoryen
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Keyword(s)Aversive Learningen
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Keyword(s)Fear Conditioningen
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Dewey Decimal Classification number(s)150
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TitlemGlu5: A double-edged sword for aversive learning related therapeuticsen
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DRO typearticleen
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Article numbere16
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Journal titleNeuroanatomy and Behaviouren
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Volume3
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Visible tag(s)Version of Record