Lifetime trauma history and cognitive functioning in major depression and their role for cognitive-behavioral therapy outcome
Author(s) / Creator(s)
Schindler, Lena
Stalder, Tobias
Kirschbaum, Clemens
Plessow, Franziska
Schönfeld, Sabine
Hoyer, Jürgen
Trautmann, Sebastian
Weidner, Kerstin
Steudte-Schmiedgen, Susann
Abstract / Description
Background: While cognitive-behavioral therapy (CBT) is the gold-standard psychological treatment for major depression (MD), non-response and lacking stability of treatment gains are persistent issues. Potential factors influencing treatment outcome might be lifetime trauma history and possibly associated primarily prefrontal-cortex- and hippocampus-dependent cognitive alterations. Method: We investigated MD and healthy control participants with (MD+T+, n = 37; MD-T+, n = 39) and without lifetime trauma history (MD+T-, n = 26; MD-T-, n = 45) regarding working memory, interference susceptibility, conflict adaptation, and autobiographical memory specificity. Further, MD+T+ (n = 21) and MD+T- groups (n = 16) were re-examined after 25 CBT sessions, with MD-T- individuals (n = 34) invited in parallel in order to explore the stability of cognitive alterations and the predictive value of lifetime trauma history, cognitive functioning, and their interaction for treatment outcome. Results: On a cross-sectional level, MD+T+ showed the highest conflict adaptation, but MD+T- the lowest autobiographical memory specificity, while no group differences emerged for working memory and interference susceptibility. Clinical improvement did not differ between groups and cognitive functioning remained stable over CBT. Further, only a singular predictive association of forward digit span, but no other facets of baseline cognitive functioning, lifetime trauma history, or their interaction with treatment outcome emerged. Discussion: These results indicate differential roles of lifetime trauma history and psychopathology for cognitive functioning in MD, and add to the emerging literature on considering cognitive, next to clinical remission as a relevant treatment outcome.
Keyword(s)
major depression lifetime trauma history working memory interference susceptibility conflict adaptation autobiographical memory cognitive-behavioral therapyPersistent Identifier
Date of first publication
2021-09-30
Journal title
Clinical Psychology in Europe
Volume
3
Issue
3
Article number
Article e4105
Publisher
PsychOpen GOLD
Publication status
publishedVersion
Review status
peerReviewed
Is version of
Citation
Schindler, L., Stalder, T., Kirschbaum, C., Plessow, F., Schönfeld, S., Hoyer, J., Trautmann, S., Weidner, K., & Steudte-Schmiedgen, S. (2021). Lifetime trauma history and cognitive functioning in major depression and their role for cognitive-behavioral therapy outcome. Clinical Psychology in Europe, 3(3), Article e4105. https://doi.org/10.32872/cpe.4105
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Author(s) / Creator(s)Schindler, Lena
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Author(s) / Creator(s)Stalder, Tobias
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Author(s) / Creator(s)Kirschbaum, Clemens
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Author(s) / Creator(s)Plessow, Franziska
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Author(s) / Creator(s)Schönfeld, Sabine
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Author(s) / Creator(s)Hoyer, Jürgen
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Author(s) / Creator(s)Trautmann, Sebastian
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Author(s) / Creator(s)Weidner, Kerstin
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Author(s) / Creator(s)Steudte-Schmiedgen, Susann
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PsychArchives acquisition timestamp2022-04-14T11:19:38Z
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Made available on2022-04-14T11:19:38Z
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Date of first publication2021-09-30
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Abstract / DescriptionBackground: While cognitive-behavioral therapy (CBT) is the gold-standard psychological treatment for major depression (MD), non-response and lacking stability of treatment gains are persistent issues. Potential factors influencing treatment outcome might be lifetime trauma history and possibly associated primarily prefrontal-cortex- and hippocampus-dependent cognitive alterations. Method: We investigated MD and healthy control participants with (MD+T+, n = 37; MD-T+, n = 39) and without lifetime trauma history (MD+T-, n = 26; MD-T-, n = 45) regarding working memory, interference susceptibility, conflict adaptation, and autobiographical memory specificity. Further, MD+T+ (n = 21) and MD+T- groups (n = 16) were re-examined after 25 CBT sessions, with MD-T- individuals (n = 34) invited in parallel in order to explore the stability of cognitive alterations and the predictive value of lifetime trauma history, cognitive functioning, and their interaction for treatment outcome. Results: On a cross-sectional level, MD+T+ showed the highest conflict adaptation, but MD+T- the lowest autobiographical memory specificity, while no group differences emerged for working memory and interference susceptibility. Clinical improvement did not differ between groups and cognitive functioning remained stable over CBT. Further, only a singular predictive association of forward digit span, but no other facets of baseline cognitive functioning, lifetime trauma history, or their interaction with treatment outcome emerged. Discussion: These results indicate differential roles of lifetime trauma history and psychopathology for cognitive functioning in MD, and add to the emerging literature on considering cognitive, next to clinical remission as a relevant treatment outcome.en_US
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Publication statuspublishedVersion
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Review statuspeerReviewed
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CitationSchindler, L., Stalder, T., Kirschbaum, C., Plessow, F., Schönfeld, S., Hoyer, J., Trautmann, S., Weidner, K., & Steudte-Schmiedgen, S. (2021). Lifetime trauma history and cognitive functioning in major depression and their role for cognitive-behavioral therapy outcome. Clinical Psychology in Europe, 3(3), Article e4105. https://doi.org/10.32872/cpe.4105en_US
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ISSN2625-3410
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Persistent Identifierhttps://hdl.handle.net/20.500.12034/5176
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Persistent Identifierhttps://doi.org/10.23668/psycharchives.5780
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Language of contenteng
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PublisherPsychOpen GOLD
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Is version ofhttps://doi.org/10.32872/cpe.4105
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Is related tohttps://doi.org/10.23668/psycharchives.5073
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Keyword(s)major depressionen_US
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Keyword(s)lifetime trauma historyen_US
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Keyword(s)working memoryen_US
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Keyword(s)interference susceptibilityen_US
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Keyword(s)conflict adaptationen_US
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Keyword(s)autobiographical memoryen_US
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Keyword(s)cognitive-behavioral therapyen_US
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Dewey Decimal Classification number(s)150
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TitleLifetime trauma history and cognitive functioning in major depression and their role for cognitive-behavioral therapy outcomeen_US
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DRO typearticle
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Article numberArticle e4105
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Issue3
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Journal titleClinical Psychology in Europe
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Volume3
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Visible tag(s)Version of Recorden_US