Depressive symptoms as a risk factor for memory decline in older adults: a longitudinal study using the dual change score model
Depression as a risk factor for memory decline in older adults.
This article is a preprint and has not been certified by peer review [What does this mean?].
Author(s) / Creator(s)
Teles, Mariana
Other kind(s) of contributor
Shi, Dingjing
Abstract / Description
Background: the direction of the longitudinal association between depression and memory remains a topic of intense debate. A unidirectional association where depression impacts the change in memory (or vice-versa) and a bidirectional association where the trajectories of both dimensions affect each other lead to different clinical implications. Method: This study aimed to investigate the directionality of the depression-memory association in a sample of 2,057 older adults aged between 60 to 99 years old from the Virginia Cognitive Aging Project (VCAP). We used the bivariate dual change score model to investigate the directionality of the association between episodic memory and three dimensions of depression (somatic, depressed affect, and positive affect) throughout ten years (five measurement points), controlling for age, education, and gender. Results: slight decline is observed for memory and stability for depression over the ages of 60 – 99. All depression scales at a given time-point predicted the subsequent change in memory with a negative association, meaning that higher depression is linked with a steeper decline in memory by the next time-point (γDep = 1.768; SE = 0.566; p < 0.05). The opposite model in which memory predicted depression and the bidirectional model were both much weaker than the depression predicting memory model. Conclusions: Our findings support a unidirectional association with depression preceding an accelerated decline in memory in older adults. We discuss the clinical implications for depression as a risk factor for a subsequent memory decline.
Persistent Identifier
Date of first publication
2021-04-27
Publisher
PsychArchives
Is version of
Citation
Teles, M. (2021). Depressive symptoms as a risk factor for memory decline in older adults: a longitudinal study using the dual change score model. PsychArchives. https://doi.org/10.23668/PSYCHARCHIVES.4787
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Unmasked manuscript.pdfAdobe PDF - 513.47KBMD5: f6504d31e3115f5df9589432f1ec895d
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Author(s) / Creator(s)Teles, Mariana
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Other kind(s) of contributorShi, Dingjing
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PsychArchives acquisition timestamp2021-04-27T12:54:38Z
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Made available on2021-04-27T12:54:38Z
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Date of first publication2021-04-27
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Abstract / DescriptionBackground: the direction of the longitudinal association between depression and memory remains a topic of intense debate. A unidirectional association where depression impacts the change in memory (or vice-versa) and a bidirectional association where the trajectories of both dimensions affect each other lead to different clinical implications. Method: This study aimed to investigate the directionality of the depression-memory association in a sample of 2,057 older adults aged between 60 to 99 years old from the Virginia Cognitive Aging Project (VCAP). We used the bivariate dual change score model to investigate the directionality of the association between episodic memory and three dimensions of depression (somatic, depressed affect, and positive affect) throughout ten years (five measurement points), controlling for age, education, and gender. Results: slight decline is observed for memory and stability for depression over the ages of 60 – 99. All depression scales at a given time-point predicted the subsequent change in memory with a negative association, meaning that higher depression is linked with a steeper decline in memory by the next time-point (γDep = 1.768; SE = 0.566; p < 0.05). The opposite model in which memory predicted depression and the bidirectional model were both much weaker than the depression predicting memory model. Conclusions: Our findings support a unidirectional association with depression preceding an accelerated decline in memory in older adults. We discuss the clinical implications for depression as a risk factor for a subsequent memory decline.en_US
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Publication statusotheren
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Publication statusotheren
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Review statusnotRevieweden
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Review statusunknownen
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CitationTeles, M. (2021). Depressive symptoms as a risk factor for memory decline in older adults: a longitudinal study using the dual change score model. PsychArchives. https://doi.org/10.23668/PSYCHARCHIVES.4787en
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Persistent Identifierhttps://hdl.handle.net/20.500.12034/4226
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Persistent Identifierhttps://doi.org/10.23668/psycharchives.4787
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Language of contentengen_US
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PublisherPsychArchivesen_US
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Is version ofhttps://doi.org/10.1016/j.archger.2021.104501
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Dewey Decimal Classification number(s)150
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TitleDepressive symptoms as a risk factor for memory decline in older adults: a longitudinal study using the dual change score modelen_US
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Alternative titleDepression as a risk factor for memory decline in older adults.en_US
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DRO typepreprinten_US